Polynucleotide vs HIFU: Advanced Skin Rejuvenation at Pure Aesthetics Nottingham
- Pure Aesthetics
- Dec 29, 2025
- 2 min read
At Pure Aesthetics Nottingham, we specialise in advanced, non-surgical skin rejuvenation treatments designed to restore youthful vitality, firmness, and radiance. Two of our most effective treatments — Polynucleotide (PN) therapy and HIFU (High-Intensity Focused Ultrasound) — both target skin ageing, but in very different and complimentary ways.
Understanding how these treatments work can help you choose the best option or combination for your skin goals...
Polynucleotide Treatment: Skin Regeneration from Within
What is Polynucleotide Treatment?
Polynucleotide (PN) treatment involves injectable, naturally occurring DNA fragments, often derived from salmon, that stimulate cellular repair and regeneration within the skin.
How Does It Work?
Polynucleotides encourage your body to naturally produce:
Collagen
Elastin
Hyaluronic acid
This improves skin hydration, elasticity, and overall quality by working at a cellular level.
Best For:
Dull or tired-looking skin
Fine lines and early signs of ageing
Improving overall skin quality and hydration
Boosting radiance and texture
Treating acne scars and sun damage
Results:
Results appear gradually over several weeks, delivering subtle, natural-looking improvements. Skin becomes smoother, plumper, and more resilient — perfect for those seeking gentle rejuvenation rather than dramatic change.
HIFU (High-Intensity Focused Ultrasound): Deep Lifting & Tightening
What is HIFU?
HIFU is a non-surgical skin tightening treatment that uses focused ultrasound energy to target deeper layers of the skin.
How Does It Work?
HIFU delivers controlled heat to deep structural layers, including the SMAS layer — the same layer tightened during surgical facelifts. This heat causes tissue contraction and stimulates intense collagen production.
Best For:
Sagging skin and loss of firmness
Lifting jowls and jawline definition
Improving facial and neck contours
Deep collagen stimulation
Results:
Patients often notice an initial tightening effect, with full results developing over 2–3 months as collagen rebuilds. Results are long-lasting, making HIFU an excellent option for those seeking a non-surgical facelift effect.
Combining Polynucleotides & HIFU for Optimal Results
Polynucleotide and HIFU treatments work beautifully together because they target different layers of the skin:
Polynucleotides improve skin quality, hydration, and cellular regeneration.
HIFU delivers deep lifting and tightening at a structural level.
When combined, they can produce firmer, smoother, and more lifted skin, offering comprehensive rejuvenation rather than treating just one concern. This approach is ideal for patients wanting both improved skin quality and visible lifting.
Which Treatment Is Right for You?
At Pure Aesthetics Nottingham, every treatment plan begins with a professional consultation to ensure your skin receives the right solution for your goals.
Choose Polynucleotides if your goal is overall skin rejuvenation, hydration, and texture improvement.
Choose HIFU if you’re concerned about sagging, laxity, and loss of facial definition.
Consider combination treatment for the most complete skin transformation.
If you’re ready to refresh, lift, and rejuvenate your skin using the latest non-surgical techniques, our expert team is here to help.
For more information please contact us or book your appointment online.
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